Castro and dos Santos were to hold talks at the presidential palace "to analyse the cooperation between their two countries," Angola's state press agency Angop reported Tuesday.
Trade delegations from the two countries were also scheduled to hold talks and sign a number of bilateral accords before an official lunch hosted by dos Santos in Castro's honour, Angop said.
In February, Castro, 78, made Angola the first African country he visited since replacing his ailing elder brother Fidel as president last year.
Cuba and Angola have close ties dating back to Angola's 27-year civil war, which broke out after independence from Portugal in 1975.